Zack Littell made two trips to Cooperstown Dreams Park. The first was with Capital City Baseball Dream (NC) during Tournament 10 in 2007 and the second with North Carolina Cardinals (NC) during Tournament 10 in 2008.

Zack graduated from Eastern Alamance High School (Mebane, NC) where he was a member of the baseball, basketball, football and wrestling teams.

Zack committed to play baseball and pitch at Appalachian State University (Boone, NC), however he was selected by the Seattle Mariners in the 2013 Major League draft and opted to go professional. In November 2016, Zack was traded to the New York Yankees then the Minnesota Twins in July 2017. He made his Major League debut on July 5, 2018.

Prior to the start of the 2023 season, Zack signed with the Texas Rangers, was traded to the Boston Red Sox in May 2023 then immediately to Tampa Bay Rays where he played until 2025. He then went to the Cincinnati Reds in July 2025, Washington Nationals in March 2026 and Arizona Diamondbacks in August 2026.